一切源自于无处不在的寂寞。当寂寞蔓延到头顶无法呼吸，过气电视明星鲍勃·哈里斯(比尔·默瑞 Bill Murray 饰)，已为人妻的夏洛特(斯嘉丽·约翰逊 Scarlett Johansson 饰)，年轻貌美的电影女演员凯莉(安娜·法瑞丝 Anna Faris 饰)在机缘巧合下在东京相遇。在这个不是故乡的陌生城市里，他们在豪华旅馆邂逅，不约而同的失眠，互相 陪伴，生活一方面仿佛变的缤纷起来，另一面却逐渐走向迷失，过气明星和为人妻的夏洛特能迎接他们二人思想和关系变化的挑战吗？冲破迷失或者身陷其中，让我们一起找寻答案。
Bob, a 55 year old, looking bored, oblivious, is a still famous actor who comes to Tokyo to shoot a commercial for $2 million. As soon he arrives and is greeted by a bunch of smiling overly friendly Japanese crew, he gets a fax from his wife Lydia, 45 years old, reminding him that he forgot his son's birthday. The next morning, he spots Charlotte, 25 years old, in the elevator full of expressionless Japanese people. Bob, feeling totally oblivious, shoots a whiskey commercial.
Charlotte is accompanying her husband John, who is 30 years old and a constantly busy photographer, who doesn't pay much attention to her. He goes to Tokyo to shoot for a few days. She feels sad, lost and alone in a luxurious hotel.
After a few days, Bob and Charlotte have a pleasant short conversation in a hotel bar. For the next few days they briefly meet, whether accidentally or on purpose. Their sympathy for one another grows.
Charlotte invites Bob to join her and friends for a party. They all have a great time together. Their understanding of each other's feelings deepens. Charlotte reveals to him her fear of not knowing what to do with her life, he tells her about the scary and troubling parts of his marriage. After going back to his room, Bob tries to share his emotions about the party with his wife over phone, but she remains cold and talks about her daily routine.
The next day, Charlotte travels to Kyoto and Bob appears as a guest in a popular but meaningless Japanese show. Still desperate about his appearance in that show, he finds himself again in the hotel bar. Charlotte is not there. The singer from a hotel approaches him and the two have a brief affair. Charlotte is disappointed about the affair the next day. They spend a terrible lunch together.
The last evening he admits that he wishes to stay in Tokyo with her. They both know their wish is just a romantic fantasy. They stay without words, holding each other's hand, and kiss gently goodbye.
Before he leaves the next morning, he calls to see her again. They say bye without a kiss, both embarrassed, not knowing exactly how to react. She walks away. On the way to the airport, he spots her from the car. He rushes toward her. They embrace warmly. He whispers to her. They kiss gently but passionately and say goodbye. He observes the city from the car, feeling happy.
