1962年10月14日，一则由飞临古巴上空U-2侦察机所拍摄照片中透露的情报信息，引发了一场当时世界两大超级大国美国与苏联之间的空前危机。美国情报官员在这组情报资料中发现，苏联正在距离佛罗里达不到150公里的古巴首都哈瓦那西南的圣克利斯托瓦尔修建基地，部署中短程导弹和运 载核武器的伊尔-28重型轰炸机，这些导弹足以摧毁全美各大城市并且造成重大伤亡。全美上下陷入极度恐慌之中，也将整个世界推向了核灾难的边缘。总统约翰·肯尼迪（布鲁斯·格林伍德 Bruce Greenwood 饰）和其弟罗伯特·肯尼迪（斯蒂文·卡普Steven Culp 饰）沉着应对这场一触即发的核战危机，影片透过白宫高级特别助理肯尼斯·奥唐纳（凯文·科斯特纳 Kevin Costner 饰）之眼，再现了危机重重的惊天十三日。
In October, 1962, U-2 surveillance photos reveal that the Soviet Union is in the process of placing nuclear weapons in Cuba. These weapons have the capability of wiping out most of the Eastern and Southern United States in minutes if they become operational. President John F. Kennedy and his advisors must come up with a plan of action against the Soviets. Kennedy is determined to show that he is strong enough to stand up to the threat, and the Pentagon advises U.S. military strikes against Cuba--which could lead the way to another U.S. invasion of the island. However, Kennedy is reluctant to follow through, because a U.S. invasion could cause the Soviets to retaliate in Europe. A nuclear showdown appears to be almost inevitable. Can it be prevented?
