在美国旧金山有一座名为“阿尔卡特拉兹”的监狱，在那里，关押着来自世界各地的冷酷凶残的重刑犯。尽管有最坚固的墙壁和最先进的监控系统，但越狱和暴乱的危机依然时刻笼罩在监狱的上空，对于守卫人员来说，每一天的工作都意味着巨大的压力和危险，只要有零星的一丁点儿火星出现，就有可能酿成无法挽回的悲剧。 最近，一个“新朋友”的到来引起了大伙儿的注意，不过，大家更感兴趣的，是这位朋友究竟将他抢劫来的巨额黄金藏在了什么地方。萨沙（史蒂文·席格 Steven Seagal 饰）是一名FBI密探，他被安插在监狱中，时刻追踪黄金的动向。在一个充满了罪犯的封闭空间里，一场恶战即将拉开帷幕。
Sascha Petrosevitch (Steven Seagal) is a car thief who's brought in by criminal Nick Frazier (Jeffrey "Ja Rule" Atkins) to work for crime boss Sonny Eckvall (Richard Bremmer), who apparently shot and killed Sascha's wife.
FBI Special Agent Ellen "E. Z." Williams (Claudia Christian) and her team show up to nail Nick, but things go bad, and Sascha gets shot.
After eight months of recovery following his brief bout of being clinically dead from the shooting, Sascha is incarcerated along with Nick in the newly reopened Alcatraz prison.
Sascha Petrosevitch (Steven Seagal) and Nick Frazier (Ja Rule).Run by the charismatic warden, Juan Ruiz "El Fuego" Escarzaga (Tony Plana), the place is known for its new state of the art death chamber where the condemned can choose from five different ways to die -- lethal injection, gas chamber, hanging, firing squad, or electric chair.
Lester McKenna (Bruce Weitz) is the first prisoner scheduled to be executed. An older man, he stole $200,000,000 worth of gold bricks in a heist that resulted in five deaths.
Federal Bureau of Prisons head Frank Hubbard (Stephen J. Cannell) and Supreme Court Justice June McPherson (Linda Thorson) have arrived to witness the execution, which is a result of June sentencing Lester.
But she's not the only one interested in Lester. A small but well-equipped team of terrorists who call themselves the "49ers" have parachuted onto the island, and gained control of it.
Led by 49er One, a.k.a. Hubbard's assistant Donny Johnson (Morris Chestnut), and 49er Six (Nia Peeples), the team finds Lester, and they want him to give up the location of his hidden stash of gold.
When Lester won't tell them, Donny shoots a nearby priest (Eva-Maria Schönecker), and threatens to kill others if the info isn't delivered.
Donny's plan is disrupted, however, when Sascha decides to step in and fight back. It turns out that Sascha is actually an undercover FBI agent who's been trying to use Nick to get to Sonny Eckvall.
When Sascha rescues Lester, the 49ers strap June to the electric chair and threaten to kill her, all while Ellen and her team prepare a rescue plan from the mainland.
With the help of Nick and some of the other inmates such as Twitch (Ricardo "Kurupt" Brown) and Little Joe (Michael "Bear" Taliferro), Sascha sets out to rescue June and bring Donny down, before Alcatraz becomes everyone's final resting place.
