莎拉·乔丹（安吉丽娜·朱莉 Angelina Jolie饰）是一位过着令人艳羡的上流生活的社会名媛，她的丈夫也是事业有成的实业家。杯觥交错的生活，原本可以一直这样富有安逸的过下去，直到她在一次慈善晚宴上邂逅了一生挚爱尼克·卡拉汉（克里夫·欧文 Clive Owen饰）——终生致力于人道主义救援的医生。 尼克常年工作在条件艰苦甚至有生命危险的国家地区，为那些身处战乱忍受饥饿疾病的人们实施医疗援助。莎拉被深深的触动了，她放弃了现有的生活，前往埃塞俄比亚与尼克的队友一起参加救援工作。从贫瘠蹂躏的埃塞俄比亚到战火纷飞的越南再到暴乱不断的车臣，这对超越边界、超越种族、超越时空的爱人，为了共同的信念，付出了一切……
BEYOND BORDERS follows the problematic blossoming romance between busy American socialite Sarah Jordan (Jolie), and rogue doctor Nick Callahan (Owen). The two initially meet in 1984 at a charity event in London. Sarah is still flushed with excitement from her recent marriage, but is nevertheless enchanted by Nick's impassioned speech on behalf of starving children in Ethiopia. Sarah decides to help the cause in Africa, meeting Nick there and sparking a romantic connection which is cut short because of family and work commitments. Four years later, Sarah finds herself alone after a torrid divorce. Her work for the United Nations now consumes her thoughts, and when the chance to travel to war-torn Cambodia--and reunite with Nick--arises, it proves too good to turn down. The two immediately hit it off, but Nick's commitment to his work once again causes them to separate. Five more years pass, and when Sarah receives a call that Nick has been captured and made a prisoner of war in Chechnya, she realizes she has one more chance to rescue her man, and to rekindle the passion.
